HDL的临床试验PPT课件.pptVIP

HDL and Coronary Heart Disease Angiographic and Clinical Event Trials Angiographic Trials of Combination Therapy Cholesterol Lowering Atherosclerosis Study (CLAS)1 Diet and niacin + colestipol (vs diet and placebo) 188 men (aged 40–59 y), post-CABG Nonsmokers or former smokers, nondiabetic, nonhypertensive Total-C at entry: 185–350 mg/dL; drug responsive Familial Atherosclerosis Treatment Study (FATS)2 Lovastatin + colestipol, niacin + colestipol, or conventional therapy 146 men (aged ? 62 y) with CAD and family history of CAD ApoB ? 125 mg/dL Average stenosis: 34% Angiographic Trials of C