斯坦福大学分子生物学课件-Replication2B课件.pptVIP

* RF-C is a five-subunit complex All subunits are related in sequence and have ATP binding motifs ATP hydrolysis by RF-C is associated with the loading of PCNA RF-C is the functional homolog of the clamp-loader g complex Polymerase switching occurs even on lagging strands; pol d does most of DNA synthesis How do you think the PCNA is removed after ligation? *