高等有机化学文献讲解课件.pptVIP

THANK FOR ALL OF YOU * * * * * * * * * * * * J. Am. Chem. Soc.?2011,?133, 8150–8153. III Synthetic Strategy IV Summary Ⅰ Background Ⅱ Retrosynthetic Analysis About the natural products Exserohilum rostratum Against human colon carcinoma Exserohilum holmii Antibacterial and antifungal activity Epicoccum nigrum Anti-HIV activity Ⅱ Retrosynthetic Analysis III Synthetic Strategy 51% 92% 86% 77% 90% 69% 54% 34% 32.5% 65% 18 24% 52% 86% 51% The?Kornblum–DeLaMare rearrangement?is a?rearrangement reaction??in which a primary or secondary?organic peroxide?is converted to the corresponding k