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催化胺化进展 【0001.】这对美国要求优先权的发明专利申请临时辑。 No. 60/340,658 which was filed Dec. 14, 2001 and which is currently still pending.第三百四十分之六十，658这是提出2001年12月14日，些是目前仍在审理中。技术领域 This invention relates to catalysts useful in the preparation of amines by reductive amination.本发明涉及的胺催化剂的还原胺化制备有用。 More particularly, it relates to catalysts and processes for their use in the production of amines from alcohols, ketones, and aldehydes.尤其是，它关系到他们的催化剂和过程中，从醇，酮，醛胺的生产和使用。 Catalysts according to the invention comprise new combinations of metallic components, which new combinations in such catalysts yield improved performance in a reductive amination process that employs the catalysts provided.根据本发明的催化剂包括金属元件，这种新组合产量提高催化剂在还原胺化的过程，采用了催化剂的性能提供了新的组合。 BACKGROUND背景Strictly speaking, “reductive amination” refers to the reaction of an aldehyde or ketone with ammonia (or a primary or secondary amine) and hydrogen in the presence of a metallic hydrogenation catalyst to give a primary, secondary, or tertiary amine product.严格地说，“还原胺化”指的是醛或酮与氨（或初级或二级胺），并在一个金属加氢催化剂的存在氢气，使小学，中学，或叔胺产品反应。 Primary and secondary alcohols also undergo the same reaction, except that hydrogen is not consumed in the reaction.小学及中学醇也经历了同样的反应，除了氢反应中不消耗。 It has been found in general that catalysts useful in reductive amination of aldehydes and ketones are also useful in the amination of alcohols, though the reduction of an alcohol in general requires considerably higher temperature.人们已经发现在一般的催化剂在醛和酮还原胺化也是有益的醇胺化的有用的，虽然在一般酒精的要求相当高的温度降低。Catalysis CROSS-REFERENCES TO RELATED APPLICATIONS 【0004】Catalysts useful in reductive amination and alcohol amination processes have been the subject of a large volume of work by chemists, and the prior art is replete with patents concerning catalytic materials and/or processes using catalytic materials as the including the following US Pat.催化剂的还原胺化，胺化进程有用酒精一直是化学家的工作量大的问题，和之前的艺术是与专利有关的催化材料和/或程序，包括利用美国专利如下充满催化材料。 Nos. 6,159,894; 6,057,442; 6,037,295; 6,046,359; 5,986,138; 5,958,825; 5,723,641; 5,367,112;