弥散张量成像技术在慢性原发性闭角型青光眼患者脑白质结构的初步应用技术报告.docVIP

弥散张量成像技术在慢性原发性闭角型青光眼患者 脑白质结构的初步应用 卢山，宋修峰，林松，李志清，李威 [摘要] 目的 采用磁共振弥散张量成像（diffusion tensor imaging，DTI）研究慢性闭角型青光眼（primary angle-closure glaucoma，PACG）患者脑白质病变，用各向异性指数（fractional anisotropy，FA）检测病变部位。方法 回顾性分析2008－2009年在眼科就诊并做颅脑MRI检查的患者，其中确诊为慢性PACG并同时行DTI扫描的患者25例（男7例，女18例，中位年龄53岁），根据视野损害程度将患者分为轻度组和重度组；选取同一时间段做颅脑DTI扫描的正常对照25例（男7例，女18例，中位年龄52岁）。采用FSL软件和DTIstudio软件处理并得到FA图，将符合要求的FA图输入SPM5软件做标准化处理，然后进行灰白质分割，对分割后的白质FA图进行平滑处理，平滑核FWHM取8mm；最后对两组FA图进行两样本t检验比较，采用FWE方法校正统计结果，取p0.05有统计学意义，将结果叠加于标准模板，显示阈值设定为10个体素。采用同样的方法计算轻度组和重度组FA图的差异。结果 剔除头动明显被试者图像后，慢性PACG组（男7例、女15例）和正常对照组（男8例、女14例）各有22例入组，轻度组例13例，重度组例9例。经统计分析慢性PACG患者双侧视束脚周段FA值明显降低（p0.05，FWE校正），左侧包含98个体素，右侧包含56个体素。轻度组与重度组FA值无显著性差异。结论 DTI可检测慢性PGCG患者脑白质结构病变，FA值可反应双侧视束脚周段病变。 [关键词] 青光眼；扩散张量；部分各向异性 Preliminary study on the brain white matter of chronic primary angle closure glaucoma by diffusion tensor imaging LU Shan*,SONG Xiu-feng,LIN Song,LI Zhi-qing,LI Wei *Metabolic Diseases Hospital of Tianjin Medical University(Key lab of hormones and development,Ministry of Health), Tianjin, 300070,China Corresponding auther: LI Wei,Email:liweizyy@ [Abstract] Objective To evaluate the brain white matter abnormality in the chronic primary angle-closure glaucoma (PACG) subjects with diffusion tensor imaging(DTI), and fractional anisotropy (FA) was used to identify the abnormal region in white matter. Methods Retrospectively analysis the data of patients in department of ophthalmology during 2008 to 2009,those who proved to be chronic PACG clinically and underwent DTI scan were recruited in the study, totally 25 patients with 7 males and 18 females.All the patient were divided into mild group and severe group accortding to the impairment of the visual field. 25 age-matched healthy subjects (7 males,18 females) who also underwent DTI scan in the same period were recruited as normal contrast. FSL and DTIstudio software were applied to calculate the FA map, SPM5 was used to segment the whole brain to get white matter FA map in a normalized space, and