围术期镇痛面面观摘要.ppt

* COX-2 selective inhibition reduces pain and inflammation without the adverse events traditionally associated with COX-1 inhibition.1,2 No effect on platelet aggregation and bleeding time2 COX-2 safety profile1,2 Reduced opioid consumption and enhanced analgesia with multimodal therapy3 Non-narcotic—not generally associated with traditional opioid side effects3 Used in conjunction with morphine as part of a multimodal pain management strategy, DYNASTAT? (parecoxib sodium for injection) has been shown to enhance the analgesic effect (vs opioids alone)4,5 Significantly lower upper GI ulceratio