白念珠菌基因变异对唑类药物耐受性研析进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 2010, 45 (7) : 821826 ·821 · 白念珠菌基因变异对唑类药物耐受性的研究进展 朱春香, 高平挥, 姜远英* (第二军医大学 学院 理教研室, 上海 200433) 摘要: 基因变异是白念珠菌产生唑类药物耐受性的主要原因之一。不同类型的变异在白念珠菌耐药性发生 进程中起着不同程度的推动作用。其中ERG 系列基因突变, 主要是影响麦角甾醇合成通路; 而白念珠菌CDR1 、 MDR1 的调控因子TAC1、Mrr1 突变影响白念珠菌 物外排泵蛋白的表达水平。此外, 基因拷贝数的变异也逐 渐受到人们的重视。因此, 白念珠菌的耐 相关基因变异研究对于探讨白念珠菌耐 机制具有积极的意义。 关键词: 白念珠菌; 耐药性; 基因变异 中图分类号: R966 文献标识码:A 文章编号: 05 13-4870 (2010) 07-082 1-06 Advances in the study of Candida albicans gene mutation on azole drug resistance * ZHU Chun-xiang, GAO Ping-hui, JIANG Yuan-ying (Depa rtment of Pharmacology, School of Pharmacy, Second M ilitary University, Shanghai 200433, China) Abstract: Gene mutation of Candida albicans is one of the main causes for azole drug resistance. Different types of variation play different roles in promoting the process of drug resistance. ERG series of gene mutations primarily affect the ergosterol synthesis pathway. When the regulatory factors TAC 1 for CDR 1 gene and Mrr 1 for MDR 1 gene generate mutations, the expression level of drug efflux pump protein in Candida albicans may be changed. In addition, gene copy number variation is also gaining attention. Therefore, the research of mutation resistance-associated genes has a positive meaning to explore the mechanism of drug resistance in Candida albicans. Key words: Candida albicans; drug resistance; gene mutation 白念珠菌是一种临床上重要的机会病原体, 随 键靶酶的变化 (EGR11 基因的突变和过表达); 多 着广谱抗生素和免疫抑制剂的广泛应用, 一些免疫 耐 蛋白表达增多;