Rasmussen脑炎.pptxVIP

Rasmussen脑炎的临床、病理及治疗进展;The 2005 European consensus remains the accepted guideline for evaluative criteria;Rasmussen脑炎（RE）临床特点;流行病学;Three disease stages RE;典型Rasmussen脑炎各期临床表现;RE其他临床特点;RE影像学特点;脑电图特点;RE脑电图特点;;诊断;Diagnostic criteria- Part A (all three);诊断标准-Part A;Diagnostic criteria- Part B;Diagnostic criteria- Part B;鉴别诊断（一）;鉴别诊断（二）;RE自然病程和免疫抑制治疗的预期影响;RE病理改变;病理;A：MAP2神经元在右侧丢失；B皮层神经元丢失，退行性改变；C同区域GFAP染色显示AST活化；D皮层神经元严重丢失；E、AST增生纤维化;F.anti-HLA-DR染色显示小胶质细胞结节形成. (G) CD68（+）显示皮层小胶质细胞的活化；(H)CD8（+）细胞毒性T细胞在皮层浸润. Higher magnifications of this section in (I) and (J) show appositions of cytotoxic T cells to neurons (arrows). (K) shows granzyme B-positive granules in close apposition to a neuron;RE发病机制;发病机制—神经免疫介导;神经免疫机制—自身抗体介导;神经免疫机制—T细胞毒性介导;小胶质细胞活化介导的退行性改变;炎性因子基因的表达 ;治疗;Antiepileptic drugs;Immunosuppressive orimmunomodulatory treatments;Proposed Strategies ;Surgery;Timing of surgery;半球切除术;语言功能的判断