1-药理学幻灯.ppt

* The normal scenario for developing a single enantiomer or isomer is that one of the isomers is more active than the the other. The other isomer could be inactive, have some activity of interest, be an antagonist of the active, have a separate activity of interest or a separate non-desirable effect causing side effects. * * 络活喜显著延缓颈动脉内膜中层厚度进展的疗效在PREVENT研究中得到充分证实。PREVENT研究是一项多中心，随机双盲安慰剂对照研究，它入选了850例诊断明确的冠心病病人。该研究结果显示：经过3年治疗，络活喜使颈动脉内膜中层厚度较基线时降低0.013mm，而安慰剂组患者的颈动脉内膜中层厚度则增加了0.033mm。络活喜较安慰剂显著延缓颈动脉IMT进展（P=0.007) 。证明络活喜有很强的抗动脉粥样硬化作用. * 5. Nissen SE, Tuzcu EM, Libby P, et al, for the CAMELOT Investig