激素替代人工周期中药疗法治疗卵巢早衰的临床研究.docVIP

激素替代人工周期中药疗法治疗卵巢早衰的临床研究 　　[摘要] 目的 考察激素替代人工周期中药疗法对卵巢早衰治疗的临床疗效。 方法 随机选取2014年7月―2015年2月入住该院的例卵巢早衰患者66例，随机分为两组。观察组33例采用激素替代人工周期中药疗法；对照组33例采用激素替代疗法，疗程 3 个月，观察临床疗效；随访 3 个月后继续观察临床疗效。结果 观察组治愈 15 例，好转 13 例，未愈 10例，总有效率为 85.84%；随访3个月，治愈7例，好转14例，未治愈12例，治愈率63.64%。血清促卵泡素（FSH）、雌二醇（E2）、促黄体生成素（LH）治疗后明显改善，差异具有统计学意义（P中国论文网 /6/view-7166426.htm 　　[关键词] 激素替代疗法；人工周期中药疗法；卵巢早衰 　　[中图分类号] R917 [文献标识码] A [文章编号] 1674-0742（2015）09（c）-0020-03 　　[Abstract] Objective To investigate the clinical effect of hormone replacement therapy combined with TCM artificial periodic therapy on premature ovarian failure. Methods 66 cases with premature ovarian failure admitted in our hospital from July 2014 to February 2015 were randomly selected and divided into two groups， the observation group and the control group with 33 cases in each. Patients in the observation group were treated by hormone replacement therapy combined with TCM artificial periodic therapy， while those in the control group were treated by hormone replacement therapy. The clinical efficacy was observed in both groups after 3-month treatment. And the clinical efficacy was observed in both groups continuously after 3-month follow-up. Results In the observation group， 15 cases were cured， 13 cases were improved， 10 cases were uncured， the total efficiency was 85.84%. After following up for 3 months， 7 cases were cured， 14 cases were improved， 12 cases were uncured， the cure rate was 63.64%. Serum follicle stimulating element （FSH）， estradiol（E2） and luteinizing hormone（LH） improved significantly after treatment， the difference was statistically significant（P 　　1 资料与方法 　　1.1 一般资料 　　随机选取2014年7月―2015年2月入住该院的卵巢早衰患者66例作为研究对象，随机进行分组，分为观察组与对照组。观察组33例，年龄 22～39 岁，平均年龄 31.5 岁；对照组33例，年龄23～38岁，平均年龄30.7岁。观察组有生育史者29例，不孕者3例；对照组有生育史者30例，不孕者2例。两组患者闭经年限均≥ 6个月， 闭经时间6个月～4年不等；伴有潮热28例，盗汗26例，伴有焦虑28例，外阴瘙痒9例，伴有阴道干涩23例，原发性不孕2例，继发性不孕7例。两组患者的性别、年龄、病情等一般临床资料差异无统计学意义（P0.05），可以纳入研究。通过B超检查卵巢子宫均小于正常形态，卵巢中有少量的卵泡生长。所有患者均间隔一个月以上测定性腺激素至少2次，结果FSH、LH值升高，尤以FSH升高明显，FSH范围在（42～115）