维持性血液透析患者血瘀证积分与ET、NO-的-相关性研究.doc

CJCM中医临床研究 2013年第 5卷第 3期 -1- 维持性血液透析患者血瘀证积分与 ET、NO的 相关性研究 Research on the correlation between blood stasis scores and ET, NO of the maintenance hemodialysis patients 徐万忠 1 李 张 思 2 昱 3 （1.泰安市中医医院，山东泰安，271000；2.顺义区中医院，北京，101300；3.中国中医科学院西苑医院，北京，100091） 中图分类号：R459.5 文献标识码：A 文章编号：1674-7860（2013）03-0001-02 证型：BDA 【摘 要】目的：探寻慢性肾衰竭维持性血液透析患者血瘀证及积分与 ET、NO的关系。方法：选取维持性血液透析血瘀证 患者 80例，检测透析前患者血 ET、NO值，并计算血瘀证积分，非血瘀证患者 40例作为对照。结果：血瘀证组 ET、ET/NO值高 于非血瘀证组（P0.05），NO值显著低于非血瘀证（P0.01）；血瘀证积分与 ET、NO有相关性（P0.05）；与 ET值呈正相关关系 （P0.01）。结论：血液透析患者血瘀证积分与 ET呈正相关关系，可以根据血瘀证积分判断患者内皮损伤和凝血功能的情况。 【关键词】维持性血液透析；血瘀证；血瘀证积分；内皮素（ET）；一氧化氮（NO）；相关性 【Abstract】Objective: To investigate the correlation between ET, NO and the formation of the blood stasis syndrome and the scores. Methods: 80 cases of blood stasis syndrome were selected to detect the levels of ET and NO by the euzymelinked immunosorbent assay, and the scores were calculated. Another 40 cases without blood stasis syndrome were selected as the control group. Results: The level of ET in the blood stasis group was higher than that in the non-blood stasis group. The level of NO in the blood stasis group was lower than that in the non-blood stasis group. The correlations between the points of the blood stasis and ET, NO had significant differences. The points of blood stasis was only positive correlated to ET by the regression analysis (P0.01). Conclusion: The level of ET, NO were correlation to the scores of blood stasis. ET was positively correlated to the scores of blood stasis. 【Keywords】 Maintenance hemodialysis; Blood stasis; Scores of blood stasis; ET; NO; Correlation doi:10.3969/j.issn.1674-7860.2013.03.001 血液透析是慢性肾衰竭发展至终末期的主要替代治疗方 法之一，但血液透析可影响血管内皮功能或造成血管内皮损 伤，引发凝血异常，导致出血或血栓、心脑血管疾病及血管通 路失功等远期并发症，严重影响患者生存质量和预后；出血或 血栓与中医学的血瘀证相类似，本研究旨在寻找慢性肾衰竭维 持性血液透析患者血瘀证及积分与 ET、NO的相关性，探讨血 管内皮损伤在血瘀证形成中作用及对血瘀证积分的影响，判断 凝血功能的情况，为应用活血化瘀法防治血液透析并发症提供 理论依据。现将研究结果报道如下。 析中应用肝素钠或低分子肝素外，平素未应用抗血小板、抗凝降 纤、降脂、改善微循环、改善内皮细胞功等影响凝血功能的药物。 剔除有急慢性感