硫酸镁联合低分子肝素治疗早发型子痫的效果观察.docVIP

硫酸镁联合低分子肝素治疗早发型子痫的效果观察 　　【摘要】 目的：观察硫酸镁联合低分子肝素治疗早发型子痫的效果。方法：选取2014年5月-2015年5月在笔者所在医院接受硫酸镁联合低分子肝素治疗的20例早发型子痫患者作为观察组，另随机选取同时期在笔者所在医院接受单纯硫酸镁治疗的20例早发型子痫患者作为对照组，对比两组治疗前后的收缩压、舒张压和24 h尿蛋白定量、凝血功能、胎儿生物物理评分及新生儿Apgar评分。结果：治疗前，两组的收缩压、舒张压和24 h尿蛋白定量比较差异无统计学意义（P0.05）。治疗后，观察组的收缩压、舒张压和24 h尿蛋白定量均优于对照组，差异有统计学意义（P中国论文网 /6/view-7255040.htm 　　【关键词】 硫酸镁； 低分子肝素； 早发型子痫 　　中图分类号 R714.2 文献标识码 A 文章编号 1674-6805（2015）33-0008-03 　　The Effect Observation of Magnesium Sulfate with Low Molecular Heparin in the Treatment of Early-onset Preeclampsia/ZHANG Jin-yan.//Chinese and Foreign Medical Research，2015，13（33）：8-10 　　【Abstract】 Objective：To observe the effect of Magnesium Sulfate with Low Molecular Heparin in the treatment of early-onset pre-eclampsia.Method：From May 2014 to May 2015 in our hospital to accept Magnesium Sulfate with Low Molecular Heparin therapy of 20 cases of early-onset preeclampsia patients were selected as the observation group，the other at the same time in the hospital were randomly selected pure Magnesium Sulfate treatment of 20 cases of early-onset preeclampsia patients as the control group，before and after treatment of systolic pressure，diastolic pressure and 24 h urine protein quantitative，coagulation function，fetal biophysical score and neonatal Apgar scoring in two groups were compared.Result：Before the treatment，two groups of systolic pressure，diastolic pressure and the 24 h urine protein quantitative differences had no significant differences（P0.05）.After treatment，the observation group of systolic pressure，diastolic pressure and the 24 h urine protein quantitative were superior to the control group，there was significant difference（P 　　First-authors address：The Second Hospital of Sanming，Sanming 366000，China 　　doi：10.14033/ki.cfmr.2015.33.004 　　早发型子痫是妊娠期常见的一种并发症，常发生于妊娠34周以前，其发病率约占妊娠期高血压疾病的0.9%。目前，早发型子痫的病因和发病机制仍未明确，但医学上普遍认为血管内皮细胞功能失调或损伤是该病发病的中心环节，血管内皮细胞损伤与患者血清中存在某种毒性因子有关，且细胞黏附分子的异常表达发挥着重要作用[1]。由于早发型子痫的发病时间早，病情进展快，母体并发后遗症严重，临床上为确保母亲安全，常采取终止妊娠来解除病因，造成人为性医源性早产。针对这一情况，应积