小金胶囊辅助治疗结节性甲状腺肿的临床疗效及安全性.docVIP

小金胶囊辅助治疗结节性甲状腺肿的临床疗效及安全性 　　[摘要] 目的 探讨小金胶囊在结节性甲状腺肿治疗中的应用价值及安全性。方法 将2013年1月―2014年12月该院收治的结甲患者随机分为观察组和对照组，对照组给予左旋甲状腺素钠片治疗，观察组辅以小金胶囊。 结果 治疗3个月后，两组痊愈率及总有效率差异无统计学意义（P0.05）。观察组不良反应治疗，同时减低左旋甲状腺素钠片剂量。对比分析两组的临床疗效以及不良反应发生情况。不良反应发生率较对照组得到了明显的降低，差异有统计学意义（P中国论文网 /6/view-7249558.htm 　　[关键词] 小金胶囊；左旋甲状腺素钠；结节性甲状腺肿 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2015）12（c）-0108-02 　　Clinical Curative Effect and Security of Xiaojin Capsules in Adjunctive Treatment of Nodular Goiter 　　XU Bin 　　Endocrinology Department， Tonghua People’s Hospital of Jilin Province，Tonghua，Jilin Province， 134001 China 　　[Abstract] Objective To discuss the application value and security of xiaojin capsules in treatment of nodular goiter. Methods The patients with nodular goiter treated in our hospital from January 2013 to December 2014 were randomly divided into two groups， the control group were treated with levothyroxine sodium tablets， the observation group were treated with levothyroxine sodium tablets supplemented by xiaojin capsules. Results After 3 months of treatment， the differences in the cure rate and total effective rate were not statistically significant（P0.05），the toxic and adverse reaction was observed and the dosage of levothyroxine was decreased at the same time， the clinical curative effect and occurrence of toxic and adverse reactions of the two groups were comparatively analyzed， the incidence of toxic and adverse reaction in the observation group was obviously decreased compared with that in the control group， and the difference was statistically significant（P0.05），具有可比性。 　　1.2 治疗方法 　　对照组常规给予左旋甲状腺素钠片（优甲乐，批号：50～100μg/次，1次/d，口服。观察组辅以小金胶囊（小金胶囊，批号：治疗，4粒/次，2次/d，口服，同时减低左旋甲状腺素钠片剂量，25～50 μg/次，1次/d，口服。治疗过程中注意观察患者症状体征及不良反应发生情况，若出现不良反应及时来院就诊，并于治疗3个月后复查评价临床疗效。 　　1.3 疗效评价标准 　　痊愈：症状消失，未触及肿块，B超示最大结节直径2/3；有效：症状好转，B超示最大结节直径缩小1/3～2/3；无效：症状改善不明显，B超示最大结节直径缩小1/3[3]。总有效率=（痊愈+显效+有效）/总例数×100%。 　　1.4 统计方法 　　应用SPSS 16.0统计学软件对数据进行处理，计数资料采用百分率（%）表示，采用χ2检验，以P0.05为差异有统计学意义。 　　2 结果 　　2.1 临床疗