冯奉仪__复发或转移性乳腺癌的治疗策略.ppt

宝山壁画 宝山壁画是引人注目的昂贵文物。此壁画发现于阿鲁科尔沁旗东沙布乡境内。1994年列为“全国十大考古新发现”之一。宝山壁画中最引人注目的是《杨贵妃教鹦鹉图》。该画高0.7米、宽2.3米，用于笔重彩绘制，最突出的表现了 晚唐风格。唐代擅长绘贵妇仕女的大师周昉绘制了《杨贵妃教鹦鹉图》，不仅享誉中原，而且还影响全国各地。发现于阿旗宝山古墓里的这幅画，就是契丹人聘请中原画家按照周氏风格绘制的， 技法深得周氏画风的真传。在唐人真迹稀如星风的今天，能够从中完整了解唐代人物画的杰出成就，堪称美术史研究的辛事。这幅壁画现今保存在阿鲁科尔沁旗博物馆，历经千年，恍如新绘，是该馆的镇馆之宝。 欢迎大家观看！ * * Eribulin: 非紫彬类的微管抑制剂 * * * Taylor等及Boccardo等的研究的结果显示，在绝经前、 ER+或未知的晚期乳腺癌的治疗中，‘诺雷得’ 3.6mg可有效取代卵巢去势 * * * * Comment: TTP similar to DFS with same medians and even smaller p-value 0,0007 DR similar in both arms A=?? ; A+H=?? Q: Is there any explanation for the initial part of the KM-plot, which shows a steep and sudden drop at roughly 2.5 months. A: At the current point in time, we cannot explain, why there is a group of patients progressing so quickly. This was not our expectation, when the trial was designed. However, it seems that the perception that a positive hormone receptor status equals a good outcome (positive prediction of response to hormonal treatment) was an overestimate in the subgroup of patients with HER2 / HR co-positive disease. As we have also seen in more recent literature (Lipton 2002, 2003; Marcom 2006) the shape of the KM-plot with the early and steep drop and the separation at 2.5 months has been seen before in this population. As the first tumour assessment for response or progression was scheduled for 9 weeks, we may actually have been missing the precise time points of progression for some of the patients, whose tumours progressed very early, which might have resulted in an earlier separation of the two curves. * * Anti-Aromatase Agents vs Tamoxifen in 1st Line Therapy of Advanced Breast Cancer : Summary Exemestane 25 mg  vs TAM Anastrozole  1 mg vs TAM Letrozole 2.5 mg vs TAM No. of patients CR + PR, % 61 vs 59 44 vs 14 325 vs 326 21.1 vs 17 453 vs 454 30 vs 20 * Clin. Benefit, % 55 vs 39* 59.1 vs 45.6* 49 vs 38* Median TTP, mo 8.9 vs 5.2 8.5 vs 7.0 9