氨基糖苷类抗生素8精要.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * 氨基糖苷类的化学结构由2个或3个氨基糖分子通过氧桥与非糖部分结构连接成苷。结构中富含氨基，呈碱性，带多个正电荷，属于多聚阳离子，极性大。这些化学性质与该类药物的抗菌作用和体内过程密切相关。 Here is the common structure of aminoglycosides. We notice they have many amino-groups. So they are polycations(多聚阳离子). That mean they have many positive charges（带正电荷）. This chemical character contributes to their antibacterial mechanism. * * * * * * * * * * * * * * * * * * Let’s see an animation. The positively charged aminoglycoside binds to negatively charged sites on the outer bacterial membrane, thereby disrupting membrane integrity. What’s more, the