第八章基因突变分析.ppt

* CPD – cyclobutane pyrimidine dimer photolyase; Many organisms don’t have this light-dependent repair by photolyases (humans?). * * UvrC has the endonuclease activity; UvrA and B bind to the damaged site. NER can also repair other types of DNA damage. Essential in humans; people with Xeroderma pigmentosum have reduced NER extreme UV sensitivity. Also, a NER deficiency in humans promotes cancer. Probably a minor pathway for dimer repair in organisms with photolyases. * DNA glycosylase cuts the bond between base and sugar. AP refers to Apurinic or Apyrimidinic nuclease. * * Dam methylase is