不同剂量hCG对体外受精-胚胎移植技术分析.docVIP

不同剂量hCG对体外受精-胚胎移植妊娠结局的影响 唐志霞，洪名云，张玲，何芳，严春 （安徽省妇幼保健院生殖中心，安徽医科大学附属临床学院，合肥，230001） [摘　要]目的：探讨使用不同剂量人绒毛膜促性腺激素（hCG）对体外受精-胚胎移植（IVF-ET）的结局及对卵巢过度刺激综合征（OHSS）发病率的影响。方法：回顾性分析2010年4月至2013年9月在本中心行IVF-ET的374例，按HCG日注射HCG的不同剂量分为A组(4 000 U),B组(5000 U),C组(6 000 U)，D组（8 000 U）和E组（ 10 000 U）。观察各组IVF结局及OHSS发生率等。结果：E组的获卵数、MⅡ数、优质胚胎数及冷冻胚胎数均低于其余各组，且有统计学差异（P 0.05）。A组的获卵数、MⅡ数、优质胚胎数均高于其余各组，且有统计学差异（P 0.05）。A组的冷冻胚胎数均高于其余各组，与除B组之外的各组相比有统计学差异（P 0.05）。B组的获卵数、MⅡ数高于D组和E组，且有统计学差异（P 0.05）。各组的获卵率、成熟率、受精率、卵裂率、妊娠率及流产率相比均无统计学差异（P＞0.05）。结论：超促排卵过程中减少使用hCG剂量对卵子的成熟、受精、胚胎质量以及移植周期临床妊娠率无明显的影响，结合全胚胎冷冻有效的预防OHSS的发生。 关键词：人绒毛膜促性腺激素; 控制性超促排卵; 受精，体外；胚胎移植； Effect of hCG at Different Dosages on the Pregnancy Outcomes of IVF-ET. TANG Zhi-xia, HONG Ming-yun, ZHANG Ling, HE Fang, YAN Chun. Reproductive Center, AnHui Province Maternity and Child Health Hospital, Hefei, 230001. 【Abstract】Objective：To investigate the effects of hCG at different dosages on the Pregnancy Outcomes of IVF-ET and rate of ovarian hyperstimulation syndrome (OHSS). Methods：Retrospectively analyzed 374 infertile women undergoing IVF-ET treatment during the period of April 2010 to September 201, Which were divided into five groups according to the different doses of HCG on hCG injection day, Group A (4 000 U), Group B (5000 U), Group C (6 000 U)，Group D（8 000 U）Group E（ 10 000 U）. We compared the pregnancy outcomes of IVF-ET and the rate of 通讯作者E-mail：tzx1999@163.com OHSS.Results：The number of egg retrieval and MⅡ, the number of high quality embryo and frozen embryo of group E was significantly Lower than those of other groups（P0.05). The number of egg retrieval and MⅡ, the number of high quality embryo of group A was significantly higher than those of other groups（P0.05). The number of frozen embryo of group A was significantly higher than those of other groups except group B（P0.05). The number of egg retrieval and MⅡof group B was significantly higher than those of group D and group E（P0.05). There was no significant difference in the