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ABSTRACT
BACKGROUND:Endometriosisisacomnlon disorder.Itisdefined
gynecological by
the ofendometrialtissueoutsidetheuterine of
presence cavity.Thepathogenesis
endometriosisremainsunclear.Thecurrent theoriescannot
etiological fullyexplain
clinicalvarietiesofendometriosis.Ris to the of
importantexplorepathogenesis
recentresearch
endometriosisandlookfornewmethodsoftreatment.Aseriesof have
in
thatdislocationofbasalendometrialstemcell resultendometriosis
suggested might
andit beastemcellrelateddisorder.
might
OBJECTIVE:The ofendometriosislesionsisdetectedwitha
proliferationclonality
stemcell EMwillbetested.
methodofmolecular of
analysis.Thehypothesis
METHODS:The ofHumARofobtainedendometriosislesions
heterozygositygene
wereidentifieda chain andSTR
by polymerasereaction(PCR)assayanalysis.The
ofEM andstromalweredetectedaftermicrodissection.
clonalitygland
EM were monoclonal of
RESULTS:55.1%oflesionsmonoclonal.The
proportions
differentEMlesionsweredifferent:OEM
44.9%(31/69),PEM84.6%(11/13),DIE
EM EM with
100%(6/6),Abdominal64.3%(10/14),Perineum40%(2/5).Compared
tissueandnormal monoclonal Was
endometrial tissue,the s
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