远志提取物促智与神经细胞损伤的保护作用研究.pdf

THESISOFMASTER’SDEGREE Pelang ABSTRACT tothe ChineseMateria rootof tenuifolia Medica,the According Polygala tohavea effect thewillandmental flame：yuanzhi)，is (Chinese guessed specialupon and the memory． powers，improvingunderstandings仃engthening Inthis tenuifoliawaschoosenasreseach．Thedriedrootsof thesis，Polygala tenuifoliawereextractedand theseven ofextractsof Polygala get parts polygala seven werescreened and was tenuifolia(Ep0．Theparts parallely,EptA3 EptB2 locatedastheactive compound． To theeffectson and and investigate ofEptlearningmemory，learningmemory mice whichareinduced and mice impaired byScopolamineaged y呷employed．In the DownTest．the for2weeks Step applicationofEptA3100、50、25mg·kg·dig the and disturbanceinmicecaused successively,improvedlearningmemory by for4weeks couldincreasetheFc￡elence and of successively spatiallearningmemory and 15monthsmices the of17monthsmices． strengtheningworkingmemory In orderto themechanismof investigate EptB2pharmacologicalactivity,the antioxidationeffectandtheeffectof onthe ofMAO·B，