调强放射治疗中射野方向优化研究.pdf

BeamOrientation for OptimizationIntensity-modulated Radiation Therapy Abstract abeam for Objective：Todevelop orientation optimizationalgorithm radiation to theinfluence intensity-modulated therapy(I～mT)，andexplore ofbeamorientatonresolutionand orientationonthe starting optimized beam and configuration，planoptiIIlization quality mixed in isbasedon linear which and algorithm integerprogrammingbinary floatvariables to are beamorientation positive employedrepresent candidatesandbeamlet inbeam intensity weights mapsrespectively．Both beamorientationsandbeam are in intensity mapssimultaneouslyoptimized the withadeterministicmethod．ResuRs：Both algorithm target coverage andcriticalstructures were this sparing significantlyimprovedusing for tested beamorientationresolutionto100 algorithm cases,decreasing reducedthe timewithout influenceon greatly optimization significant plan different orientations quality,whileselecting had influence．