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ABSTI认CT
ObIjective:,
in
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Choriocarcinomaisa tumor,which
highlymalignant
isSOfarthemaintreatment·
chi offemales.Chemotherapy
ld—bearingages
leadsto
choriocarcinomaisthe causewhich
resistanceto primary
Drug
lure.Itcanbe talor after
treatmentfai congeniacquired
is
ofthe resistanceinchoriocarcinomaacquired,including
drug
calmechanisms.This isbasedonthe
caland study
cytologi
pharmacologi
intracellular5-FU/FUDRmetabolic identify
understood pathway,to
clearly
ofrelated inthe
betweenthe enzymespathway
theconnection expression
gene
cells.
andthe resistanceofchoriocarcinoma
drug
Method:
doubltime
ing
curve,cellcycle,population
Thechemosensitivity,growth
different
weredetermined assays.Thegene
and expression through
P-gp
metabolic
intheintracellular5-FU/FUDR
the involved
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