沙格列汀的作用机制.绪论.pptx

沙格列汀的作用机制;肠促胰岛激素简史;;;Role of Incretin System in Glucose Homeostasis ;GLP-1和GIP 是两类主要的肠促胰素;The Incretin Effect is Reduced in Type 2 Diabetes;Incretin hormone changes;Continuous Infusion of GLP-1 Decreases Fasting Glucose as well as HbA1c;;在2型糖尿病的治疗中，针对GLP-1的药物更有价值;;GLP-1在人体的作用;胰高血糖素样肽-1 (GLP-1);Glucose-Dependent Effects of GLP-1;T2DM中胰岛α细胞对葡萄糖的敏感性降低; 糖尿病前期胰高糖素异常;胰高血糖素受体敲除小鼠血糖水平降低;T2DM是胰岛素分泌不足和胰高糖素分泌增加致高血糖;GLP-1降低1型糖尿病患者的胰高糖素和血糖水平;GLP-1抑制胰高糖素分泌并非由胰岛素介导;GLP-1在体内快速降解;DPP4抑制剂作用机理;临床药效学:稳定状态下，血浆中不同剂量的DPP-4 活性;DPP-4抑制剂沙格列汀具有双重作用机制;;入选标准;有效性终点;b-Cell Stimulation by Saxagliptin in Patients with T2