微量残留病检测在急性白血病剖析.ppt

交叉系列抗原: B、T、髓、NK细胞抗原 非同期抗原共表达: CD15/CD117 CD34/CD64 抗原表达量异常：表达强度过高、过低或不表达 异常的光散射信号：FSC和SSC AIEOP-BFM ALL 2000化疗流程 MRD-directed risk group stratification HR:PPR;NR,BCR/ABL,MLL/AF4 QR-PCR 检测MRD流程 Event-free survival cumulative incidence of relapse Blood.2010;115:3206 Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute Lymphoblastic leukemia:results in 3184 patients of the AIEOP-BFM ALL 2000 study TEL/AML1+ favorable DNA index ( 1.16 and 1.6; B) Prognostic impact of PCR-MRD Ph+