心血管系统建模介绍.pptVIP

心血管系统建模 生物医学工程 07硕士 付秀泉 人体循环系统组成 心脏 动脉 静脉 外周血管网络 体循环 脉管模型重要参数 阻抗：血液在血管中流动时因其粘滞性而 受到的阻力 脉管模型重要参数 容积：血管的弹性令它在受到透壁压的时 候发生舒张，改变容积 电路模型类比 体循环的集中参数模型 假设血流为0，出现一个系统平均填充压Pms Pa = Pv = Pf = Pms Ct为系统总容积 Pms =(Vt ? V0)/Ct Windkessel简化模型 如果我们把注意力限制在大动脉上，并认为静脉的压力是常量，并近似为0，那么可以把外周循环简化为Windkessel模型。 心室模型 心室压力-容量关系 心-肺泵单元 完整心血管系统电路模型 研究动态 联合助搏器测试的心血管仿真 左心室模型与任意循环模型的耦合仿真算法 由压力反射效应调节的心血管数学模型 Hardware-in-the-loop-simulation of the cardiovascular system, with assist device testing applicationB.M. Hanson et al. [J] ELSEVIER, Medical Engineering Physics 29 (2007) 367–374 The paper presents a technique for evaluating the performance of a cardiac assist device prior to in vivo trials by combining physical (mechanical) testing with a numerical, computerised model of a biological system. This Hardware-in-the-loop simulation combines a realistic numerical model of the heart and cardiovascular system with a controllable physical heart simulator. Numerical model of cardiovascular system Heart Simulator Applying mechanical assistance in the form of direct cardiac compression can increase blood pressure and cardiac output from a weakened heart. Compared to testing on an animal model, it is possible to perform repeated experiments, all on an identical patient model, in a short space of time, in a non-clinical setting. Compared with a purely numerical simulation, HIL simulation enabled evaluation of the effect of the real, physical performance of the prototype assist device. Simulation Algorithm for the Coupling of the Left Ventricular Mechanical Model with Arbitrary Circulation ModelYutaka NOBUAKI et al. Engineering in Medicine and Biology 27th Annual Conference2005, 7632-7635 Cardiovascular dynamics is the result of the nonlinear interactions between the left ventricular mechanical model and the circulation model, simultaneous calculation of both models by a strong coupling method is necessary to obtain an accurate simulation result. Left Ventricular Model Left