小剂量阿司匹林联合肝素和地屈孕酮治疗不明原因复发性-中国药物评价.docVIP

小剂量阿司匹林联合肝素和地屈孕酮治疗复发性流产的疗效观察 孙梅芳 母华欣 丹东市妇女儿童医院妇产科 118000 【摘要】目的 小剂量阿司匹林联合肝素和地屈孕酮复发性流产（RSA）的临床疗效。 方法 将258例RSA患者随机分为观察组（122例）和对照组（136例）。观察组予小剂量阿司匹林联合肝素和地屈孕酮治疗。对照组予黄体酮和人绒毛膜促性腺激素治疗。对两组患者的妊娠结局、药物不良反应及妊娠期并发症进行比较。结果 观察组总有效率（足月产+早产）高于对照组（ P ＜0.05）。两组药物不良反应发生率差异无统计学意义（ P＞ 0.05）。两组妊娠期并发症的发生率差异有统计学意义（ P ＜0.05）。结论 小剂量阿司匹林联合肝素和地屈孕酮治疗RSA能提高妊娠成功率，该方法安全有效，值得临床推广。 【关键词】复发性流产；阿司匹林；肝素；地屈孕酮 Curative Effect Observation of low-dose Aspirin in Combination with Heparin and Dydrogesterone Treatment Recurrent Spontaneous Abortion SUN Meifang，MU HuaxinDepartment of Gynaecology and Obstetrics dandong Women and Children’s Hospital ,dandong 118000, China 【Abstract】 Objective To investigate the clinical efficacy of low -dose aspirin，the heparin and the dydrogesterone in the treatment of recurrent spontaneous abortion. Methods In 258 patients with recurrent spontaneous abortion patients were randomly divided into observation group 122 cases and control group 136 cases . The observation group treated with aspirin，heparin and dydrogesterone therapy. The control group treated with progesterone and chorionic gonadotropin therapy. To compare the outcome of pregnancy，adverse drug reactions，blood coagulation index and pregnancy complications of the two groups.Results The therapeutic efficacy was statistically significant between observation group and control group(P＜0.05) . Drug side effects of the two groups had no statistical significance (P＞0.05). pregnancy complications of the two groups had statistical significance(P＜0.05). Conclusions low-dose aspirin combined with Heparin and dydrogesterone in the treatment of recurrent spontaneous abortion can improve the success rate of pregnancy. This method is safe and effective and is worthy of clinical promotion. 【Keywords】Recurrent Spontaneous Abortion；Aspirin；Heparin；Dydrogesterone　 复发性流产（RSA）是指同一性伴侣连续发生3次或3次以上自然流产，但大多数专家认为连续发生2次流产即予以重视并积极处理，因为其再次流产的风险与3次者相近[1]。该病影响因素较多，其中遗传因素、子宫病变、内分泌失调、自身免疫性疾病等都是较确定的原因，但是仍有30%-40%的患者病因未明，约1/3的患者发病与血栓前状态有关[2]。近年来应用阿司匹林