细胞膜及其表面2课件.ppt

 ;;  ;;  ;;  ;;;  ;气体性(NO);激活的催化结构域;  ;;  ;  ;  ;  ;  ;  ;;;细胞表面受体和细胞内受体;G-protein linked receptor;单体型受体;Acetylcholine receptor;受体的结构示意图; ? C-terminal: Ser(丝)and Thr (苏)----rich. ? Seven-α helix transmembrane; ---the sites of phosphorylation make for the desensitization of GPLR. ; G蛋白偶联系统的组成：1.表面受体； 2.G蛋白；3.效应物(又称为膜结合机器)。; Robert J. Lefkowitz Born: 1943, New York, NY, USA Affiliation at the time of the award: Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA; Brian K. Kobilka Born: 1955, Little Falls, MN, USA Affiliation at the time of the award: Stanford University School of Medicine, Stanford, CA, USA;The Nobel Prize in Chemistry 2012 to them:“for studies of G-protein-coupled receptors”;;;糖酵解;;信号转导(通过第二信使);Earl W. Sutherland,Jr. Born: 19 November 1915, Burlingame, KS, USA Died: 9 March 1974, Miami, FL, USA Affiliation at the time of the award: Vanderbilt University, Nashville, TN, USA;The Nobel Prize in Physiology or Medicine 1971 to him:“for his discoveries concerning the mechanisms of the action of hormones” ;; ;G蛋白分子开关; Afred G Gilman Born: 1 July 1941, New Haven, CT, USA Affiliation at the time of the award: University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; Martin Rodbell Born: 1 December 1925, Baltimore, MD, USA Died: 7 December 1998, Chapel Hill, NC, USA Affiliation at the time of the award: National Institute of Environ-mental Health Sciences, Research Triangle Park, NC, USA;The Nobel Prize in Physiology or Medicine 1994 to them:“for their discovery of G-proteins and the role of these proteins in signal transduction in cells” ;磷酸化; Edmond H. Fischer Born: 6 April 1920, Shanghai, China Affiliation at the time of the award: University of Washington, Seattle, WA, USA; Edwin G. Krebs Born: 6 June 1918, Lansing, IA, USA Died: 21 December 2009, Seattle, WA, USA Affiliation at the time of the award: University of Washington, Seattle, WA, USA;The Nobel Pr