表观遗传学染色质重塑资料.pptxVIP

染色质重塑Chromatin Remodeling;;简介;We focus on dynamic chromatin from the perspective of chromatin remodelers and discuss recent advances in how they are specialized for the processes listed above, how they move or restructure nucleosomes, how they are targeted and regulated, and how mutations in remodelers impact development and human disease. ;Why Do Cells Need Remodelers?;;;;Dynamic Range of Chromatin Structure Created by ATP-Dependent Chromatin Remodeling;; one remodeler per nucleosome multiple enzymatic reactions destabilize 1 nucleosome 14 histone-DNA contacts use ATP hydrolysis to br