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（要旨テンプレート）英語タイトル（Arial）10ポイント ○Katsuyoshi CHIBA1 , Chieko KASAI1 , Mitsuyasu TABO2 , Kohei SAWADA2 　英語氏名（Arial）10ポイント 1 Safety Pharmacology Assessment Dept., RD Division, Nihon Okusuri Co., Ltd. 2 Pharmacology Assessment Dept., RD Division, Nihon Okusuri Co., Ltd.　英語所属機関名（Arial）10ポイント [Introduction]Times New Roman（英語） 特別講演／シンポジウム／一般演題（口述／ポスター） Usefulness of common marmosets to detect drug-induced QT interval prolongation: moxifloxacin case study ○Katsuyoshi CHIBA1 , Chieko KASAI1 , Mitsuyasu TABO2 , Kohei SAWADA2 1 Safety Pharmacology Assessment Dept., RD Division, Nihon Okusuri Co., Ltd. 2 Pharmacology Assessment Dept., RD Division, Nihon Okusuri Co., Ltd. [Introduction] Moxifloxacin is the most widely used positive reference agent in clinical cardiac repolarization studies, but it has not been characterized in common marmosets which are uniquely suited to studies in early-stage development due to their small size and minimal test article requirements. The purpose of this study was to evaluate the sensitivity of the common marmoset to detect moxifloxacin-associated QT interval prolongation. [Methods] Eight telemetered common marmosets were monitored for 24 h following oral administration of moxifloxacin by gavage at 0, 10, 30, and 100 mg/kg using a Latin square design. Concurrently, a pharmacokinetic evaluation in 8 non-telemetered animals was conducted. A rate-corrected QT QTc interval was derived using an individual probabilistic QT rate-correction. QTc placebo-adjusted QTc change from the individual baseline was calculated and the relationship between pharmacokinetics PK and pharmacodynamics PD was analyzed. [Results] A slight, but not significant, increase in QTc was detected with 10 mg/kg of moxifloxacin. Moxifloxacin at 30 and 100 mg/kg elicited dose-dependent increases in QTc correlated with the plasma concentration of moxifloxacin. From the PK/PD relationship, the plasma concentration which would attain QTc of 5 to 10 ms was estimated to be 1