治疗药物监测解说.ppt

治疗药物监测 目 录 理论与方法 流程与要点 回顾与展望 治疗药物监测－理论与方法 定义 治疗药物监测（Therapeutic Drug Mornitoring，TDM）又称临床药动学监测（clinical pharmacokinetic monitoring, CPM），是指根据药动学原理，采用现代分析手段，对血液和其他体液中的药物浓度进行测定并取得有关参数，为临床用药科学化、个体化、合理化提供依据，从而提高药物疗效，避免药物中毒反应。 ——《实验诊断学》 Definitions of  Therapeutic Drug Monitoring  -IATDMCT Proposed by Standards of Laboratory Practice Committee, 2003 Approved by Executive Committee, 2004 Amended by IATDMCT Executive Committee, 2011 Therapeutic drug monitoring is defined as “ the measurement made in the laboratory of a parameter that, with appropriate interpretation, will directly influence prescribing procedures ”. Commonly the measurement is in a biologic matrix of a prescribed xenobiotic, but it may also be of an endogenous compound prescribed as replacement therapy in an individual who is physiologically or pathologically deficient in that compound TDM is a multi-disciplinary clinical specialty aimed at improving patient care by individually adjusting the dose of drugs for which clinical experience or clinical trials have shown it improved outcome in the general or special populations. It can be based on a prior pharmacogenetic, demographic and clinical information, and/or on the a posterior measurement of blood concentrations of drugs (pharmacokinetic monitoring) and/or biomarkers (pharmacodynamic monitoring) a priori TDM: consists of determining the initial dose regimen to be given to a patient, based on clinical endpoint and on established population pharmacokinetic-pharmocodynamic (PK/PD) relationships. These relationships help to identify sub-populations of patients with different dosage requirements, by utilizing demographic data, clinical findings, clinical chemistry results, and/or, when appropriate, pharmacogenetic characteristics. a posteriori TDM: includes pre-analytical, analytical and post-analytical phases, each with the same importance; is most often base