胆汁盐和卵磷脂的相互作用要点.pptxVIP

background The aqueous self-assembly of amphiphiles is driven by hydrophobic interactions in low-polarity organic liquids reverse self-assembly attractive forces, such as hydrogen bonding interactions cyclohexane环己烷 n-decane正癸烷 functional groups efficiencies AR2000EX(高级旋转流变仪） SANS and SAXS FT-IR Rheology SC SDC STC STDC. B0=BS/PL B0max phase separates ? OPO? CA DCA COOH STC STDC SC SDC -OH FT-IR ↑ hydrogen bonds C=O the hydrogen bonds between water and C=O are relatively weak and water molecules interact with C=O only after the phosphate groups are fully hydrated p = atail/ahg Oil reverse micelles p 1 reverse spherical micelles to reverse cylindrical micelles p must decrease. SC and SDC ahg is largely increased whereas atail is maintained about the same and thus p decreases quickly STC and STDC 1 the molecules are longer and the amide groups . Although ahg is increased, atail is also slightly increased. the efficiency to decrease p is lower than that of SC and SDC 2 the missing OH of STDC is the one in the middle of the steroid rings, The OH group at this position may still increase ahg more than atail so that STC is more efficient than STDC CA and DCA ?mostly distributed around the areas of phosphates and glycerol esters so that they are less able to expand the choline ? very low efficiencies to decrease p, ?unable to induce sufficiently long wormlike micelles before phase separation. CONCLUSIONS SC SDC STC STDC CA DCA the positions of the primary groups are the key to modulating the self-assembly. Thank you