JieunParkChem-5398.pptVIP

Drug therapy – MAO-B Inhibitors Side effects of L-DOPA may be enhanced by selegeline. Nausea and dizziness. * Treatment – Drug Therapy Catechol O-Methyl Transferase (COMT) Inhibitors Inactivates and degrades neurotransmitters, such as dopamine. Mainly used in combination with L-DOPA, it increases the half-life of L-DOPA. Delays “wearing-off” effect of L-DOPA and other motor complications such as dyskinesia * Tolcapone(Tasmar ?) Drug therapy – COMT Inhibitors COMT catalyses methylation of L-DOPA. Addition of COMT inhibitor along with L-DOPA and carbidopa prolongs the half-life of L-DOPA and in