乳腺癌患者血清中ccl18及il-6表达水平关系的探讨.docVIP

CCL18、IL-6及TNF-α在乳腺癌患者血清中表达水平关系的探讨 漆起贵1，李正艳2，王玉凤 3,张守丹1，李翠宁1，许燕艳1，岳莉1 (1.辽宁医学院，辽宁 锦州,12100；2.滕州市中心人民医院，山东 滕州市,277500；3.齐齐哈尔医学院第一附属医院，黑龙江 齐齐哈尔，161041） 【摘要】目的:探讨乳腺癌患者外周血清中CCL18、IL-6和TNF-α表达水平的关系。方法:采用ELISA法检测61例乳腺癌患者血清CCL18、IL-6和TNF-α的表达水平，并以24例乳腺良性病和18例健康体检者做对照，组间水平的比较采用t检验。结果：CCL18、IL-6和TNF-α表达水平在健康体检者组，乳腺良性病组和乳腺癌组血清中依次升高，差异具有统计学意义(P＜0.05）；三者水平在乳腺癌组随临床分期增加而升高，各期水平的差异有统计学意义（P＜0.05）。结论：CCL18、IL-6和TNF-α在乳腺癌中的表达水平密切相关，可以作为判定乳腺癌发展及预后的重要生物学指标。 【关键词】乳腺癌 ；CCL-18；IL-6；TNF-α；血清 英文标题：to explore the relationship between the expression of CCL18、 IL-6 and TNF-αin the serum of patients with breast cancer Qi QG1 ,Li ZY2，Wang YF3,Zhang SD1,Li CN1,Xu YY1,Yue L1 （1.liaoning medical university,Liaoning Jinzhou,121001；2. the center hospital of tengzhou, Shandong, 277500; 3. the first affiliated hospital of Qiqihar College, Heilongjiang, 161041) 【Abstract】Objective:To investigate the expression relationship of CCL18，IL-6 and TNF-αin peripheral serum with breast cancer. Methods:We detected 61 cases of breast cancer patients with CCL18,IL-6 and TNF-αexpression,and to 24 cases of benign breast disease and 18 healthy subjects as controls by ELISA method，the level of the comparison between the two groups using t test. Results: The expression Of CCL18,IL-6 and TNF-αin the healthy subjects group, benign breast disease group and in turn increase the serum of breast cancer, the difference was statistically significant (P 0.05); three levels with the clinical breast cancer group increases with period, each period the level of difference was statistically significant (P 0.05). Conclusion: The expression Of CCL18,IL-6 and TNF-αin breast cancer is closely related in the development and prognosis of breast cancer ,they can be to determine the importance of biological indicators. 【Key words 】breast cancer；CCL18；IL-6；TNF-α；serum 近年来研究发现炎症因子是乳腺癌发生和发展的危险因素，参与机体炎症反应的因子有CCL18、IL-6和TNF-α等。本文我们对61例乳腺癌，24例乳腺良性疾病和18例正常人外周血清中CCL18、IL-6和TNF-α的表达水平进行了测定，并探讨三者与乳腺癌的关系。 1. 资料与方法 1.1 一般资料 乳腺癌组61例（II期19例，III期28例，IV期1