酶通论1.pptVIP

Section 2.1 Introduction of enzyme Key terms Enzyme ribozyme Biocatalyst Substrate reactant Product cofactor apoenzyme holoenzyme coenzyme prosthetic group transition state activation energy equilibrium active site specificity induced fit Lock and key turnover number 2.1.1 The study history of enzymes Urease crystals ( X 728)Sumner, J. B. (1926) “ The isolation and crystallization of the enzyme urease” J. Biol. Chem. 69:435-441. Not all enzymes are proteins:Some RNA molecules (ribozymes) were found to be catalytic (Thomas Cech, 1981).Ribozymes are involved in RN