专业英语(第一次修改).pptVIP

Synthesis, characterization and bioactivity of Fipronil derivativesas a lead for new insecticide 领先的新型杀虫剂氟虫腈衍生物的合成、表征及生物活性的研究 目录 1 Abstract 摘要 2 Introduction 前言 3 Experimental Procedure 实验程序 4 Results and Discussion 结果与讨论 5 Conclusion 结论 Abstract Fipronil is the first phenylpyrazole insecticide introduced for pest control. In order to further study fipronil derivatives of better bioactivity and systemic property derived from the pyrazole-5-amine by addition reaction /elimination /substitution reaction, ten modified compounds were prepared. Their insecticidal bioactivities against the 3rd instar larvae of Plutella xylostella were determined. The data suggested that bioactivities of most of the compounds are higher than that of fipronil,while some of them showed only modest activity as compared with fipronil. 摘要 氟虫腈是第一种进行病虫害防治的苯基吡唑类农药。为了进一步研究氟虫腈衍生物最好的生物活性和5-氨基吡唑系统的性质，通过加成/消除/取代反应制备了十种修饰后的化合物。并测定了对小菜蛾第三龄幼虫的杀虫活性。数据表明，大多数化合物的生物活性高于氟虫腈，而他们中的一些比氟虫腈只显示出少量的活性。 氟虫腈的化学名称:5-氨基-3-氰基-1-(2,6-二氯-4-三氟甲基-苯基)-4-三氟甲基亚砜基-吡唑 设计、改变氟虫腈的化学结构来研究构效关系和合成方法，制备并筛选出生物活性更好的氟虫腈衍生物，使其具有更大的实际应用价值。 前言 Introduction Fipronil research led to commercial operations firstly by French Phone Poulenc Company registered in China in 1992. It was the first phenylpyrazole insecticide introduced for pest control. This second generation insecticide acting on the GABA receptor, interfering with the nerve system of insect by blocking the chloride channel led to insect death in a certain dose1. Internationally, fipronil is considered as the new generation, high-tech pesticide for its novel structure, unique action mechanism and high activity. This was followed by its derivatives some of which have been commercialized2,3. In 2004, Mitsubishi Chemical Co., Japan reported 2 new fipronil derivatives, pyrafluprole (V3039) and pyriprole (V3086) with improved synthesis method. These derivatives exhibited better biological activity than fipronil. In the mean ti