基底硬度和细胞密度对骨髓间充质干细胞骨分化的影响和机理研究.pdf

Effects of Matrix Elasticity and Cell Density on Human Mesenchymal Stem Cells Osteo/Chondro Differentiation and Mechanism Study A Thesis Submitted to Chongqing University in Partial Fulfillment of the Requirement for the Doctor ’s Degree of Engineering By Ruyue Xue Supervised by Prof. Li Yang Assistant Supervised by Prof. Shu Chien Specialty：Biomedical Engineering College of Biogineering of Chongqing University, Chongqing, China April 2013 中文摘要 摘 要 骨髓间充质干细胞（Mesenchymal stem cells, MSCs ）作为成体干细胞中最重要 的一种，是一类具有多向分化潜能 （Multiple differentiation potentiality ）的细胞， 能够向神经细胞，肌细胞，成骨细胞，软骨细胞以及脂肪细胞等方向分