Primary afferent neurons of the gut.pptVIP

Intramuscular array (IMA) 肌肉内末梢 Location: within the muscle Forms: Consisting of an array of terminals running parallels to the muscle fiber Tracing of a single axon ending as several overlapping intramuscular arrays (IMAs) in the ventral forestomach of the rat. The parent axon branches several times (A) before terminating within the circular muscle layers. Upon entering the muscle, the individual terminals run for several millimeters, creating a distinct pattern of parallel elements (B–D). In panel (E), processes from the ending pass adjacently to a cluster of myenteric neurons. This afferent’s parent axon divided into five second-order branches which in turn divided into 39 higher order terminal telodendra (终树突), forming a presumptive receptive field 4.93 mm long by 0.32 mm wide. Distribution of IGLEs and IMAs. IGLEs: the esophagus and small intestine IGLEs and IMAs: mixed innervation of the stomach IMAs: the lower esophageal sphincter and pyloric sphincter 幽门括约肌 Topographic maps and plots illustrating the density and distribution of IGLEs and IMAs in stomach.  Function of IGLEs and IMAs IGLES, with their global distribution throughout the GI tract, may be a general type of tension receptor in the gut, detecting and then coordinating complex rhythmic motor movements. IMAs, with a more focal innervation pattern in regions which exhibit frequent, sustained non-rhythmic adjustments, may be a special type of mechanoreceptor which detects muscle stretch and/or length. Physiological importance of muscle receptors reflex regulation of gastrointestinal function. Receptors in the esophagus are responsible for initiating secondary peristalsis Afferent fibers from corpus 胃体 could play a role in signaling the initial phase of postprandial satiety, and may also give rise to the feeling of fullness experienced after a large meal. Serve as the afferent pathway for a number of vagovagal reflex, such as: Reflex excitation of antral motility Gastric secret