前列环素在风湿疾病的应用分析.pptVIP

还能显著减轻风湿性疾病患者疼痛。与对照组相比，两组具有显著性差异 RESULTS: There?was a trend towards fewer digital ulcerations in the BPS group than the placebo group (48.1 vs 58.8%, delta = 10.7%, p = 0.325), and median survival without recurrence of digital ulceration was longer in the BPS group (log-rank test, p = 0.233). Overall well being improved significantly more in the BPS group (p = 0.047), and von Willebrand factor decreased significantly more in the BPS group (p = 0.0001). The trend towards fewer digital ulcerations was more markedly in favor of BPS in the distal SSc group (delta for digital ulceration = 20.9%, p = 0.248) with a later onset (log-rank test, p = 0.057). Fewer patients were hospitalized in the BPS than the placebo group (4.0 vs 17.4%, p = 0.18). Side effects were mild. * Giant capillaries 是一个病理指标， 当出现时代表疾病的早期，特别是风湿疾病。凯那显著减少患者giant capillary数量。 * 血管性假性血友病因子(vWF),内皮功能损害的重要标志物之一 血中Von-Willebrand因子(血管性假性血友病因子，VwF)水平增高，说明硬皮病血管炎患者的内皮细胞被激活。VwF因子有活化血小板和促进血小板粘附的作用，促发血管内凝血，还能使成纤维细胞趋化和分裂的作用，使成纤维细胞分泌大量胶原，导致内膜纤维化。由损伤的血管壁向外渗透时，可导致外膜和血管周围组织纤维化。 而凯那能显著降低血管假性血友病因子减轻血管内皮损害。 * 有一个125例雷诺现象患者入选的试验，该试验把患者分为了贝前组和安慰剂组，来观察贝前的治疗效果。 研究的是雷诺现象的发生频率、严重程度，总体致残率等 J Rheumatol. 1996 Nov;23(11):1917-20. Controlled multicenter double blind trial of an oral analog of prostacyclin in the treatment of primary Raynauds phenomenon. French Microcirculation Society Multicentre Group for the Study of Vascular Acrosyndromes. Vayssairat M. Author information H?pital Tenon, Paris, France. Abstract OBJECTIVE: To compare the efficacy and tolerance of beraprost sodium, an oral prostanoid prostaglandin I2 analog, with a placebo in patients with primary Raynauds phenomenon (RP). METHODS: 125 patients with disabling primary RP participated in a multicenter, randomized, double blind trial in 2 parallel groups, lasting 8 weeks, and conducted during the winter months only; a meteorological survey was also conducted for each patient. Main outcome measures were frequency and severity of attacks of RP, overall disabil