养心汤联合氯氮平治疗复发精神分裂症的效果.docVIP

养心汤联合氯氮平治疗复发精神分裂症的效果 　　[摘要] 目的 探讨养心汤联合氯氮平治疗复发精神分裂症的效果。 方法 选取2014年1～12月在北京市昌平区中西医结合医院住院的复发精神分裂症患者60例，将其随机分为实验组和对照组，每组30例。实验组采用养心汤和氯氮平治疗，对照组用安慰剂和氯氮平治疗。疗程4周。观察两组临床疗效，比较两组治疗前后不同时间点阳性与阴性症状量表（PANSS）、临床总体印象量表（CGI-S）、Sheehan残疾量表（SDS）、世界卫生组织生存质量测定量表简表（WHOQOL-BREF）评分情况。 结果 治疗4周后，实验组有效率（70.00%）显著高于对照组（35.71%），差异有统计学意义（P 0.05）。 结论 养心汤联合氯氮平治疗方案可有效提高临床疗效，改善复发精神分裂症患者的症状，尤其对阴性症状改善明显。 　　[关键词] 养心汤；氯氮平；复发精神分裂症 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1673-7210（2016）04（a）-0119-04 　　Ef[Abstract] Objective To investigate the efficacy of Yangxin Decoction combined with Clozapine in the treatment of recurrent chizophrenia. Methods Sixty patients with recurrent schizophrenia hospitalized in Changping Hospital of Integrated Chinese and Western Medicine from January to December 2014 were selected and randomly divided into experimental group and control group， with 30 cases in each group. Experimental group was given Yangxin Decoction and Clozapine， the control group was given placebo and Clozapine. The course was 4 weeks. The clinical efficacy of the two groups was observed， and the scores of positive and negative syndrome scale （PANSS）， clinical global impression-severity （CGI-S）， Sheehan disability scale （SDS） and World Health Organization quality of life-brief （WHOQOL-BREF） at different time points before and after treatment were compared. Results After treatment for 4 weeks， the effective rate of experimental group （70.00%） was higher than that of control group （35.71%）， the difference was statistically significant （P 0.05）. Conclusion Yangxin Decoction combined with Clozapine can effectively improve clinical efficiency and the symptoms of patients with recurrent schizophrenia， especially for the improvement of negative symptoms. 　　[Key words] Yangxin Decoction； Clozapine； Recurrent schizophrenia 　　精神分裂症是严重危害人类健康最常见的重性精神疾病之一[1]，我国精神分裂症终身患病率为6.55‰[2]，药物维持治疗是防止该病复发最主要的手段。临床研究表明，目前仍约有30%的精神分裂症患者对抗精神病药物疗效欠佳或无效[3]。有临床调查发现，非典型抗精神病药氯氮平可以使30%～60%既往治疗无效的难治性精神分裂症患者获得显著的临床改善[4]。精神疾病长期住院患者氯氮平的使用