多索茶碱在慢性阻塞性肺炎治疗中的临床探讨.docVIP

多索茶碱在慢性阻塞性肺炎治疗中的临床探讨 　　[摘要] 目的 研究多索茶碱在慢性阻塞性肺炎治疗中的临床应用效果。 方法 随机选自该院2014年2月―2015年2月收治的100例慢性阻塞性肺炎患者作为研究对象，随机分组为对照组与观察组，每组50例，对照组采用氨茶碱治疗，观察组实施多索茶碱治疗。两组患者持续治疗2周，观察两组患者临床治疗效果，以及治疗期间出现的不良反应状况。 结果 两组患者持续治疗2周后，观察组的总有效率100%，明显高于对照组的80%，两组相比较差异有统计学意义（P0.05）；且不良反应发生率明显少于对照组。两组相比较差异有统计学意义（P0.05）。 结论 多索茶碱在治疗慢性阻塞性肺炎疾病时能够发挥较为显著的疗效，且不良反应发生率低，安全性高，临床可对其进行推广应用。 　　[Abstract] Objective To research the clinical application effect of doxofylline in treatment of chronic obstructive pneumonia. Methods 100 cases of inpatients with chronic obstructive pneumonia treated in our hospital from February 2014 to February 2015 were selected as the research object and randomly divided into two groups with 50 cases in each， the control group were treated with aminophylline， the observation group were treated with doxofylline， both groups were treated for two weeks continuously， the clinical treatment effect and adverse reaction condition during treatment of the two groups were observed. Results The total effective rate in the observation group was obviously higher than that in the control group after two weeks of continuous treatment， （100% vs 80%）， the difference was statistically significant by comparison and had comparability， （P0.05）； the incidence of adverse reaction was obviously lower than that in the control group， the difference was obvious with statistically significance（P0.05）. Conclusion Doxofylline in treatment of chronic obstructive pneumonia has an obvious curative effect and low incidence of adverse reactions with high security， which can be promoted and applied in clinic. 　　[Key words] Doxofylline； Chronic obstructive pneumonia； Aminophylline； Clinical effect 　　慢性阻塞性肺炎又称阻塞性肺气肿，是终末细支气管远端部分，如肺泡管、呼吸性细支气管、肺泡囊等部位膨胀，并伴有气腔壁破坏的现象[1]。据相关统计数据表明，我国患慢性支气管炎占3.9%，50岁以上达15%，近2年更有上升趋势[2]。因为慢性阻塞性肺炎病变不明显，病程迁延较长，长期影响患者的健康，同时给社会生产和经济均带来巨大损失[3]。临床研究发现，多索茶碱在治疗慢性阻塞性肺炎疾病方面具有较为突出的效果，获得广大医学者的广泛关注[4]。该研究随机选取该院2014年2月―2015年2月收治的100例慢性阻塞性肺炎患者，对其随机分为对照组与观察组，分别进行氨茶碱治疗与多索茶碱治疗，观察临床治疗效果，现报道如下。 　　1 资料与方法 　　1