头孢氨苄与罗红霉素在医院获得性肺炎中的应用价值评价.docVIP

头孢氨苄与罗红霉素在医院获得性肺炎中的应用价值评价 　　【摘要】 目的：探讨头孢氨苄与罗红霉素在医院获得性肺炎（HAP）中的应用效果。方法：回顾性分析本院2011年4月-2014年4月收治的86例医院获得性肺炎患者的临床资料，根据治疗方法不同分为两组，观察组46例给予头孢氨苄与罗红霉素联合治疗，对照组40例给予氟喹诺酮类抗生素治疗，比较两组临床疗效、实验室检查指标、住院时间、退热时间及肺炎严重程度（PSI）评分。结果：两组治疗有效率、外周血WBC、N%、CRP水平及住院时间、退热时间、PSI评分比较，差异均无统计学意义（P0.05）。结论：头孢氨苄与罗红霉素抗生素联合应用于医院获得性肺炎中的临床效果与单用氟喹诺酮类抗生素相近，联合应用在医院获得性肺炎治疗中具有重要的价值。 　　【关键词】 头孢氨苄； 罗红霉素； 抗生素； 医院获得性肺炎 　　【Abstract】 Objective：To investigate the effect of Cefalexin and Roxithromycin in the treatment of hospital acquired pneumonia（HAP）.Method：The clinical data of 86 hospital acquired pneumonia patients in our hospital from April 2011 to April 2014 were retrospectively analyzed.They were divided into two groups according to different treatment methods.46 patients in the observation group were treated with Cefalexin and Roxithromycin，40 patients in the control group were treated with fluoroquinolones antibiotic.The clinical curative effect，laboratory indicators，hospitalization time，cooling time and the score of the severity of pneumonia（PSI） were compared between the two groups.Result：The differences in the treatment effective rate，the levels of WBC，N%，CRP and the hospitalization time，cooling time，PSI score between the two groups were not statistically significant（P0.05）.Conclusion：Cefalexin combined with Roxithromycin in the treatment of hospital obtained pneumonia has similar clinical effect with fluoroquinolones antibiotic in the treatment of hospital obtained pneumonia.It has important application value in the treatment of hospital obtained pneumonia. 　　【Key words】 Cephalexin； Roxithromycin； Antibiotics； Hospital acquired pneumonia 　　First-author’s address：The People’s Hospital of Yichun City，Yichun 336000，China 　　doi：10.3969/j.issn.1674-4985.2016.07.041 　　大型回顾性队列研究报道结果提示对于医院获得性肺炎（hospital acquired pneumonia，HAP）的治疗常规使用头孢氨苄与罗红霉素或单独应用氟喹诺酮类抗生素进行抗感染治疗，有效的抗感染治疗有利于改善医院获得性肺炎患者的预后状况[1]。但有关研究显示，头孢氨苄与罗红霉素联合应用存在不合理性，两者联合应用于医院获得性肺炎的治疗存在着多种争议[2]。头孢氨苄与罗红霉素联合应用在医院获得性肺炎中的作用研究较少，因此，笔者分析头孢氨苄与罗红霉素在医院获得性肺炎