来氟米特与甲氨蝶呤联合应用治疗早期严重类风湿性关节炎的疗效观察.docVIP

来氟米特与甲氨蝶呤联合应用治疗早期严重类风湿性关节炎的疗效观察 　　【摘 要】目的：观察来氟米特与甲氨蝶呤联用治疗早期严重类风性关节炎的临床治疗效果，评价其安全性及临床应用价值。方法：选择我院2010年6月―2012年6月期间收治的早期严重类风湿性关节炎患者共120例，随机将患者分为观察组和对照组，每组各60例，观察组给予患者来氟米特与甲氨蝶呤联合治疗，对照组给予单一的甲氨蝶呤治疗，对两组患者治疗效果及治疗前后相关临床指标进行观察，进行比较分析。结果：观察组患者治疗前后在关节肿胀、关节压痛数、晨僵时间等的差值明显优于对照组，观察组治疗的有效率也显著高于对照组，差异均具有统计学意义（P0.05）。结论：来氟米特与甲氨蝶呤联用治疗早期类风湿性关节炎患者，有显著的临床疗效，且安全、可靠，不良反应可耐受，值得临床推广应用。 　　【关键词】类风湿性关节炎；甲氨蝶呤；来氟米特；疗效观察 　　【文章编号】1004-7484（2014）06-3775-01 　　Leflunomide and methotrexate combined use of early treatment of severe rheumatoid arthritisThe curative effect of observation. 　　Zhang jinying， Yu lili. The municipal of Laixi Shandong，266600，China. 　　【Abstract】Objective：To observe to fluorine， and methotrexate combination in treatment of early severe rheumatoid arthritis clinical treatment effect and evaluate its safety and clinical application value.Methods：select our hospital during June 2011 - June 2013 were a total of 120 patients with early severe rheumatoid arthritis， patients randomly divided into observation group and control group， 60 cases in each group， the observation group was given to fluorine， and methotrexate in patients with combined treatment， the control group given single methotrexate treatment， the therapeutic effect in patients with two groups and related clinical indexes were observed before and after the treatment， comparative analysis.Results：The observation group of patients before and after treatment in a number of joint swelling， joint tenderness， morning stiffness time， etc. The difference is superior to control group， observe the efficient treatment group was also significantly higher than that of control group， the differences were statistically significant （P 0.05）.Conclusion：To fluorine， and methotrexate combination treatment of early rheumatoid arthritis patients， significant clinical efficacy， and safe， reliable， adverse reactions can be tolerated， worthy of clinical popularization and application. 　　【Key words】Rheumatoid arthritis；Methotrexate；Fro