生物化学 Chapter 14.pptVIP

* * * * * * * * Protein phosphorylation and dephosphorylation The rate of glycolysis in mammals is mainly controlled at the step acted by phosphofructokinase-1 (PFK-1) PFK-1 catalyzes an irreversible and exergonic reaction, which commits glucose to the glycolysis pathway (away from the pentose phosphate pathway). PFK-1 is a complex tetrameric enzyme regulated by multiple intracellular signals (allosteric effectors): ATP, citrate being negative ones; AMP, ADP and fructose 2,6-bisphosphate as positive ones. Allosteric regulation of muscle PFK-1 by ATP Regulators that affect PFK-1 activity H