动脉粥样硬化药物治疗及丹参酮的进展概览.ppt

Effect of Tanshinone IIA on oxidative stress Xu S, et al. Transl Res. 2012, 160(2):114-24. * Effect of Tanshinone IIA on oxLDL-induced NF-κB activation A C Xu S, et al. Arch Biochem Biophys. 2011, 515:72–79. Xu S, et al. Transl Res. 2012, 160(2):114-24. * Effect of Tanshinone IIA on foam cell formation Xu S, et al. Transl Res. 2012, 160(2):114-24. * * ERK/Nrf2/HO-1 is involved in effect of Tanshinone IIA on cholesterol accumulation * A B Effect of Tanshinone IIA on cholesterol content and cholesterol metabolism in ApoE-/- mice fed with HCD Liu Z, et al. J Lipid Res. 2014, 55: 201–213. * Effect of Tanshinone IIA on expressions of scavenger receptors and cholesterol transporters in macrophages Liu Z, et al. J Lipid Res. 2014, 55: 201–213. * Effect of Tanshinone IIA on expressions of HO-1 Nrf2 Liu Z, et al. J Lipid Res. 2014, 55: 201–213. C D * Tanshinone IIA regulates cholesterol metabolism via HO-1 Liu Z, et al. J Lipid Res. 2014, 55: 201–213. * Tanshinone IIA regulates Nrf2/HO-1 pathway via ERK Liu Z, et al. J Lipid Res. 2014, 55: 201–213. * * Conclusions Tanshinone IIA has potent anti-atherosclerosis effect. Tanshinone IIA does not modulate the lipid profile, but inhibits foam cell formation. Tanshinone IIA attenuates oxLDL-induced LOX-1 activation via suppressing NF-κB. Tanshinone IIA attenuates cholesterol accumulation via ERK/Nrf2/HO-1 axis. * The normal muscular artery and the cell changes that occur during disease progression to thrombosis are shown.?a, The normal artery contains three layers. The inner layer, the tunica intima, is lined by a monolayer of endothelial cells that is in contact with blood overlying a basement membrane. In contrast to many animal species used for atherosclerosis experiments, the human intima contains resident smooth muscle cells (SMCs). The middle layer, or tunica media, contains SMCs embedded in a complex extracellular matrix. Arteries affected by obstructive atherosclerosis generally have the structure of muscular arteries.