Effectofcombinationgenetherapyonleftventricular.pptVIP

Effect of combination gene therapy on left ventricular myocardial functions echocardiography . Samson Mathews Samuel et al. Diabetes 2010;59:51-60 ?2010 by American Diabetes Association Effect of combination gene therapy on left ventricular myocardial functions echocardiography . A: Representative echocardiograph pictures of parasternal short axis images after 30 days of surgery and therapy. Bar graphs represent LVIDs in systole in mm B , % ejection fraction C , % fractional shortening D , and heart rate in beats/min E . There was a significant increase in the myocardial functions in the CVAMI and DVAMI groups compared with the CLZMI and DLZMI groups, respectively. CS black solid bars , nondiabetic control sham; DS gray solid bars , diabetic sham; CLZMI white bar , nondiabetic control animals that received Ad.LacZ injections; DLZMI diagonal brick bar , diabetic animals that received Ad.LacZ injections; CVAMI wave bar , nondiabetic control animals that received combination gene therapy; and DVAMI wide upward diagonal bar , diabetic animals that received combination gene therapy. Values given as mean ± SEM. *P ≤ 0.05 when DS is compared with CS, #P ≤ 0.05 compared with CLZMI, ?P ≤ 0.05 when DVAMI is compared with DLZMI.