RACKtheorytodetermineisoenzyme-specificmolecular.pptVIP

RACK theory to determine isoenzyme-specific molecular function of PKCs Upon stimulation, inactive PKC translocates to its corresponding isoenzyme-specific subcellular location to phosphorylate location-specific downstream substrates. G.R. Budas et al. Biochm. Soc. Trans. 2007;35:1021-1026 ?2007 by Portland Press Ltd RACK theory to determine isoenzyme-specific molecular function of PKCs Upon stimulation, inactive PKC translocates to its corresponding isoenzyme-specific subcellular location to phosphorylate location-specific downstream substrates. The destination of subcellular translocation is