Chapter3.淋巴组织和器官课件.pptVIP

1.Rearrangement of TCR gene T-cell maturation involves rearrangements of the germ-line TCR genes The resulting TCR are diverse and need to be selected to remove self-reactive TCRs and those can not bind to MHC molecules 2. Selections: (from DP to SP) To ensure the mature T cell to Positive selection Negative selection Recognize antigen peptide combined with the MHC molecules----- MHC restriction Be unresponsive to self components---- Self tolerance Positive selection (thymic education): thymocytes in the cortex with TCRs with a moderate affinity for self-MHC molecules on epithelial