SATURN研究解读.ppt

Percentage Atheroma Volume PAV is calculated by expressing the atheroma volume B-A as a percentage of the volume of the vessel contained within the EEM B throughout the region of interest. So as a formula this becomes: PAV ∑ B – A x 100 ∑ B ? * * The primary endpoint of the study is change in PAV in a target segment of coronary artery assessed which must be at least 40mm in length . Change in PAV will be calculated by subtracting the PAV prior to treatment from the PAV at the end of the study. For regression this number will be a negative value. Abbreviations PAV percent atheroma volume; IVUS intravascular ultrasound * The secondary IVUS endpoint is change in ‘normalised’ TAV of the targeted coronary artery. Normalised TAV will be calculated as the average atheroma area multiplied by the median number of comparable cross sections in all patients in the analysis. Normalising in this way adjusts for pullbacks of differing lengths thereby resulting in an equal weighting of each individual patient. Abbreviations IVUS intravascular ultrasound; TAV total atheroma volume * Baseline demographics for the population of patients completing the trial with an evaluable final IVUS procedure. * Baseline demographics for the population of patients completing the trial with an evaluable final IVUS procedure. * Baseline demographics for the population of patients completing the trial with an evaluable final IVUS procedure. * Baseline demographics for the population of patients completing the trial with an evaluable final IVUS procedure. * * * * * * * * Results for the population of patients completing the trial with an evaluable final IVUS procedure. * Results for the population of patients completing the trial with an evaluable final IVUS procedure. 1.8是上限，并非下限 * * * * * * Whilst it is acknowledged that there are limitations in comparing data and results from different studies, this slide summarises the data from several IVUS studies and pro