溶血磷脂G蛋白偶联受体绪论.ppt

* 黄文龙 2015年7月9日 The many biological responses documented for lysophospholipids that include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P)can be mechanistically attributed to signaling through specific G protein-coupled receptors. In this brief review, we note cogent features of lysophospholipid receptors, including the current nomenclature, signalingproperties, development of agonists and antagonists,and physiological functions G蛋白偶联受体（G Protein-Coupled Receptors， GPCRs），是一大类膜蛋白受体的统称。这类受体的共同点是其立体结构中都有七个跨膜α螺旋，且其肽链的C端和连接第5和第6个跨膜螺旋的胞内环上都有G蛋白（鸟苷酸结合蛋白）的结合位点。