SafetyHandlingofCytotoxicDrug解析.ppt

Safety Handling of Cytotoxic Drug Jane Jia 2011-7 What is Cytotoxic Drug? Cytotoxic drugs are toxic compounds and are known to have carcinogenic, mutagenic and/or teratogenic potential. With direct contact they may cause irritation to the skin, eyes, and mucous membranes, and ulceration and necrosis of tissue. *The toxicity of cytotoxic drugs dictates that the exposure of health-care personnel to these drugs should be minimized. At the same time, the requirement for maintenance of aseptic conditions must be satisfied. LAMINAR FLOW BIOLOGICAL SAFETY CABINET Step 1 Step 2 Step 3 Step 4 Step 5 Step 6 PERSONAL PROTECTIVE EQUIPMENT (PPE) PERSONAL PROTECTIVE EQUIPMENT (PPE) EQUIPMENT Vials containing drugs requiring reconstitution should be vented to reduce the internal pressure with a syringe. This reduces the probability of spraying and spillage. A sterile alcohol pad should be carefully placed around the needle and vial top during withdrawal from the septum. The external surfaces contaminated with a drug should be wiped clean with an alcohol pad prior to transfer or transport When opening the glass ampule, wrap it and then snap it at the break point using an alcohol pad to reduce the possibility of injury and to contain the aerosol produced. Clean up the cabinet with alcohol. At the end of work sessions, allow BSC to operate for at least 30 minutes more to purge the work zone of aerosols. Remove protective clothing according to PPE instruction. Wash hands after removing protective clothing. Discard used gown as cytotoxic waste. Disposal of Cytotoxic Waste Disposal of Cytotoxic Waste Documentation Extravasation Extravasation Extravasation Extravasation Extravasation Extravasation Irritant: An agent which can cause aching, tightness and phlebitis at the injection site or along the vein, with or without inflammatory reaction Vesicant: A chemical compound that causes severe skin, eye and mucosal pain and irritation. They are