差示扫描量热法测定药物多晶态相对稳定性精编.doc

差示扫描量热法测定药物多晶态相对稳定性 摘要：在药物的研发过程中，待选药物必须经过测试以鉴别和定性其可能的多晶型。如果多晶型具有不同的晶体结构，那么它们的物理属性和化学属性都会存在差异，而这两方面的属性会影响药物的性能。该论文介绍了如何利用差示扫描量热法来确定多晶型系统的特性。 Abstract：In the process of developing pharmaceutical products, candidates must be tested to identify and characterize any polymorphic forms of the compound. If the polymorphic forms have different crystalline structures, there may be differences in both their physical and chemical properties, which could affect their performance as drug substances. This paper describes the use of DSC to determine the characteristics of a polymorphic system. ??? 某种化合物发展为候选药